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Association of Choroidal Interleukin-17-Producing T Lymphocytes and Macrophages with Geographic Atrophy
Serge Camelo1, Sophie Lavelette, Xavier Guillonneau
1Unitx00E9; de Recherche Clinique Lariboisix00E8;re Saint-Louis, AP-HP, Paris, France.
Purpose:
To evaluate the presence of interleukin-17 (IL-17)-producing cells in patients with geographic atrophy (GA).
Methods:
In this short report, we analyzed IL-17, CD3, and IBA-1 expression by immunohistochemistry on paraffin-embedded sections from 13 donors with a known history of GA, confirmed by fundus appearance and histology, and 7 age-matched control donors.
Results/Conclusion:
We showed that IL-17+ cells are found near areas of retinal pigmented epithelium atrophy in the eyes of GA patients. IL-17+ cells mainly localized to CD3+ cells, which identifies T lymphocytes, as well as IBA-1+ cells, which identifies mononuclear phagocytes. Therefore, IL-17 could be involved in the pathological mechanisms that contribute to the degeneration observed in GA.
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