Related Experiment Video

Updated: Mar 19, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
06:47

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

Published on: December 5, 2020

7.5K

Anti-fungal potential of ozone against some dermatophytes

Salama A Ouf1, Tarek A Moussa1, Alshimaa M Abd-Elmegeed2

  • 1Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt.

Brazilian Journal of Microbiology : [Publication of the Brazilian Society for Microbiology]
|June 12, 2016
PubMed

Insights

Ozonized oil effectively inhibited dermatophyte growth and enzyme activity, outperforming gaseous ozone. This study highlights ozonized oil as a potent agent against common fungal skin infections.

Area of Science:

  • Mycology
  • Dermatology
  • Ozone Therapy

Background:

  • Dermatophytes cause superficial fungal infections (dermatophytoses) by invading keratinized tissues.
  • Understanding their biological properties is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the impact of gaseous ozone and ozonized oil on key properties of six dermatophyte species.
  • To compare the efficacy of gaseous ozone versus ozonized oil against dermatophytes.

Main Methods:

  • Exposure of dermatophytes to gaseous ozone and ozonized oil.
  • Assessment of fungal sporulation, mycelial nutrient leakage, and hydrolytic enzyme activity.
  • Comparative analysis of treatment effects on different dermatophyte genera (Epidermophyton, Microsporum, Trichophyton).

Main Results:

  • Ozonized oil demonstrated greater efficacy than gaseous ozone against dermatophytes.
  • Microsporum gypseum and Microsporum canis showed higher susceptibility to ozonized oil.
  • Ozonized oil treatment led to reduced sporulation, increased electrolyte/sugar leakage, and diminished enzyme activity (urease, amylase, phosphatase, lipase, keratinase).

Conclusions:

  • Ozonized oil is a promising therapeutic agent for dermatophytoses.
  • The antifungal mechanism involves disruption of cell integrity and inhibition of essential enzymes.
  • Differential susceptibility among dermatophyte species warrants further investigation for targeted therapies.
Keywords:
DermatophytesDermatophytosisHydrolytic enzymesOzoneOzonized oil

More Related Videos

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

21.4K
Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.6K

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
1
Oxidative Cleavage of Alkenes: Ozonolysis01:46

Oxidative Cleavage of Alkenes: Ozonolysis

In ozonolysis, ozone is used to cleave a carbon–carbon double bond to form aldehydes and ketones, or carboxylic acids, depending on the work-up.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
13.4K
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
2.0K
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
13
Microbial Bioremediation of Pesticides01:28

Microbial Bioremediation of Pesticides

Pesticides often feature structurally complex chemical architectures, incorporating halogen groups and multiple aromatic rings. These characteristics confer high chemical stability, rendering many pesticides resistant to natural degradation processes. This resistance poses significant environmental concerns, as persistent pesticide residues can accumulate in ecosystems and affect non-target organisms.Despite the inherent stability of many pesticides, certain microorganisms possess the metabolic...
1
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.8K