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Four C1q domain-containing proteins involved in the innate immune response in Hyriopsis cumingii

Ling-Ling Zhao1, Min Jin2, Xin-Cang Li3

  • 1College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei, 430070, PR China; Jiangsu Key Laboratory for Biodiversity & Biotechnology and Jiangsu Key Laboratory for Aquatic Crustacean Diseases, College of Life Sciences, Nanjing Normal University, Nanjing, 210046, PR China.

Fish & Shellfish Immunology
|June 12, 2016
PubMed

Insights

Four C1q domain-containing (C1qDC) genes were identified in Hyriopsis cumingii. These C1qDC proteins show binding activity against bacteria, suggesting a role in anti-bacterial immunity.

Area of Science:

  • Immunology
  • Marine Biology
  • Genomics

Background:

  • C1q is a crucial component of the complement system, featuring a globular C1q (gC1q) domain with ligand-binding capabilities.
  • C1q domain-containing (C1qDC) proteins, characterized by the presence of a gC1q domain, are found in various invertebrates and play a role in recognizing non-self ligands.

Purpose of the Study:

  • To identify and characterize C1qDC genes in the mollusk Hyriopsis cumingii.
  • To investigate the expression patterns and potential immune functions of these identified C1qDC genes.

Main Methods:

  • Gene identification and sequence analysis of four C1qDC genes (HcC1qDC1-HcC1qDC4) from Hyriopsis cumingii.
  • Phylogenetic analysis and tissue distribution studies.
  • Assessment of recombinant HcC1qDC protein binding activity against bacterial species.

Main Results:

  • Four HcC1qDC genes were identified, encoding proteins with a C-terminal gC1q domain; HcC1qDC4 also possesses a coiled-coil region.
  • Phylogenetic analysis indicated significant divergence among the HcC1qDC proteins.
  • HcC1qDC genes were widely expressed across various tissues and showed differential regulation in response to bacterial stimuli.
  • Recombinant HcC1qDC proteins demonstrated binding activity towards different bacterial species.

Conclusions:

  • The identified HcC1qDC genes in Hyriopsis cumingii are widely distributed and responsive to bacterial challenges.
  • The observed binding activities suggest that HcC1qDC proteins likely contribute to the anti-bacterial immune defense mechanisms in this species.

Keywords:
Bacterial bindingC1qDC proteinHyriopsis cumingiiInnate immunity

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