Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD4<sup>+</sup> T cells reactive to Epstein-Barr virus late lytic antigens are enriched in individuals with multiple sclerosis.

Science translational medicine·2026
Same author

Association of epiretinal membranes with disability in people with multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

High-dose <i>N</i>-acetyl cysteine reduces GFAP levels: Exploratory results from a pilot double-blind, placebo-controlled randomized trial.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Concerns regarding the 2024 revisions of the McDonald criteria for diagnosis of multiple sclerosis.

The Lancet. Neurology·2026
Same author

Diagnostic performance of central vein sign and paramagnetic rim lesion integration for multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Cardiovascular comorbidities are associated with cross-sectional and longitudinal measures of multiple sclerosis fatigue.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026

Related Experiment Video

Updated: Mar 19, 2026

Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images
06:48

Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images

Published on: January 7, 2019

9.6K

Subcortical grey matter volumes predict subsequent walking function in early multiple sclerosis.

Bardia Nourbakhsh1, Christina Azevedo2, Amir-Hadi Maghzi3

  • 1Department of Neurology, University of California San Francisco, San Francisco, CA, United States.

Journal of the Neurological Sciences
|June 12, 2016
PubMed
Summary

Subcortical grey matter atrophy in early multiple sclerosis (MS) is linked to worsening disability. Thalamus, caudate, and putamen volumes at baseline predict future changes in walking and cognitive function.

Keywords:
AmbulationAtrophyGrey matterMultiple sclerosis

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.2K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

41.0K

Related Experiment Videos

Last Updated: Mar 19, 2026

Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images
06:48

Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images

Published on: January 7, 2019

9.6K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.2K
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
12:50

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Published on: April 14, 2014

41.0K

Area of Science:

  • Neuroimaging
  • Neurology
  • Neurodegeneration

Background:

  • Subcortical grey matter atrophy is associated with disability in multiple sclerosis (MS).
  • The relationship between early-stage tissue loss and disability progression in MS remains unclear.

Purpose of the Study:

  • To investigate the association between subcortical grey matter volumes and clinical disability outcomes in early MS.
  • To determine if initial subcortical structure volumes predict future disability changes.

Main Methods:

  • Serial brain MRI and clinical assessments were performed on relapsing MS patients within 12 months of onset.
  • Automated FreeSurfer pipeline measured thalamic, putamen, caudate, pallidum, and cerebellar cortical volumes.
  • Mixed-effects models analyzed associations between imaging metrics and Expanded Disability Status Scale (EDSS), Multiple Sclerosis Functional Composite (MSFC) scores.

Main Results:

  • Thalamus, caudate, and putamen volumes significantly decreased over 36 months; pallidum and cerebellar cortical volumes did not.
  • Baseline thalamus, caudate, and putamen volumes predicted subsequent changes in the timed 25-foot walk test and MSFC.
  • A trend suggested baseline caudate volume predicted timed 25-foot walk test changes; no association with EDSS changes was observed.

Conclusions:

  • Subcortical grey matter volumes in early MS are significantly associated with subsequent changes in disability measures.
  • These findings highlight the prognostic value of subcortical neuroimaging in early multiple sclerosis.