Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cohesins02:20

Cohesins

5.8K
Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of...
5.8K
Cohesins02:20

Cohesins

2.4K
2.4K
Condensins02:15

Condensins

4.8K
Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
4.8K
Condensins02:15

Condensins

2.2K
2.2K
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

4.7K
At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
4.7K
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

2.5K
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A dynamic meiotic cohesin complex regulates synaptonemal complex assembly in Drosophila oocytes.

Genetics·2026
Same author

RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription.

Molecular cell·2026
Same author

Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich's ataxia.

Molecular cell·2026
Same author

RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions.

Nature communications·2026
Same author

The cytoskeleton contributes to abnormal genome-lamina interactions in LMNA-deficient cardiomyocytes.

The Journal of cell biology·2026
Same author

A genetic screen for modifiers of cohesin clustering identifies regulators of genome folding.

Science advances·2026

Related Experiment Video

Updated: Mar 19, 2026

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline
09:14

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline

Published on: September 13, 2022

3.2K

Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation.

Mercedes R Gyuricza1, Kathryn B Manheimer1, Vandana Apte1

  • 1Waksman Institute and Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

Current Biology : CB
|June 14, 2016
PubMed
Summary

Drosophila meiosis utilizes two distinct cohesin complexes for synaptonemal complex assembly and sister-chromatid cohesion. These complexes, involving proteins like C(2)M and ORD, have unique functions and regulation.

Keywords:
chromosome segregationcohesincohesionmeiosissynaptonemal complex

More Related Videos

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets
10:52

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets

Published on: August 13, 2016

10.3K
Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes
12:46

Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes

Published on: December 6, 2017

12.1K

Related Experiment Videos

Last Updated: Mar 19, 2026

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline
09:14

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline

Published on: September 13, 2022

3.2K
Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets
10:52

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets

Published on: August 13, 2016

10.3K
Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes
12:46

Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes

Published on: December 6, 2017

12.1K

Area of Science:

  • Cell Biology
  • Genetics
  • Molecular Biology

Background:

  • Synaptonemal complex (SC) assembly in Drosophila is orchestrated by two independent pathways.
  • These pathways are defined by the chromosome axis proteins C(2)M and ORD.
  • C(2)M is a Kleisin-like protein, and ORD is crucial for sister-chromatid cohesion.

Purpose of the Study:

  • To investigate the hypothesis that the two SC assembly pathways depend on distinct cohesin complexes.
  • To elucidate the roles of mitotic cohesion proteins Stromalin (SA) and Nipped-B (SCC2) in meiosis.

Main Methods:

  • Single- and double-mutant analysis in Drosophila.
  • Study of mitotic cohesion proteins Stromalin (SA) and Nipped-B (SCC2) during meiosis.

Main Results:

  • Evidence for at least two meiosis-specific cohesin complexes.
  • One complex (C(2)M, SA, Nipped-B) is involved in homolog interactions, with minor sister-centromere cohesion roles.
  • A second complex (SOLO, SUNN, ORD) is essential for sister-chromatid cohesion and localizes to centromeres.

Conclusions:

  • Two meiosis-specific cohesin complexes possess unique functions and distinct regulatory mechanisms.
  • Multiple cohesin complexes likely provide functional diversity for meiotic processes.
  • A dynamic complex may regulate meiotic recombination, while a stable complex ensures sister-chromatid cohesion.