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Related Experiment Video

Updated: Mar 19, 2026

Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus

Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus

Published on: June 6, 2025

Stress response in medically important Mucorales.

Pankaj Singh¹, Saikat Paul¹, M Rudramurthy Shivaprakash¹

¹Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

|June 14, 2016

Summary

Rhizopus arrhizus exhibits superior resistance to osmotic and oxidative stress compared to other Mucorales species. This enhanced stress tolerance may explain its significant pathogenic potential in humans.

Keywords:

Mucorales pH stress response

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Area of Science:

Mycology
Environmental Microbiology
Pathogen Biology

Background:

Mucorales are ubiquitous fungi capable of infecting diverse human hosts.
Fungal survival in human hosts necessitates robust stress response mechanisms.

Purpose of the Study:

To investigate the abiotic stress tolerance of eight pathogenic Mucorales species.
To identify species-specific variations in fungal responses to environmental stressors.

Main Methods:

Exposure of Mucorales species to osmotic, oxidative, pH, cell wall, and metal ion stresses.
Comparative analysis of growth and survival rates under various stress conditions.

Main Results:

Significant variation in stress tolerance was observed among the tested Mucorales species.
Rhizopus arrhizus demonstrated maximum resistance to osmotic and oxidative stresses.
Species exhibited differential tolerance to acidic/alkaline pH and specific metal ions (Cu, Zn, Fe).

Conclusions:

Rhizopus arrhizus displays higher overall stress tolerance compared to other Mucorales species studied.
The superior stress resilience of R. arrhizus likely contributes to its increased pathogenic potential.