Related Experiment Video
Updated: Mar 19, 2026
Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model
Published on: December 2, 2022
Protective effect of α-mangostin against iodixanol-induced apoptotic damage in LLC-PK1 cells
Dahae Lee1, Young Ok Choi2, Ki Hyun Kim3
1School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea; College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea.
Abstract:
Radiographic contrast media facilitate the visibility of internal body structures, but its use to patients with lowered renal function needs to be careful because of severe side effect in kidney. The present study aims to evaluate potential protective effect and mechanism of Alpha mangostin (α-mangostin) against contrast-induced apoptotic damage in LLC-PK1 cells. As a result, α-mangostin in non-toxic concentrations improved the viability of the iodixanol-treated cells up to 90.42% against contrast-induced damage in LLC-PK1 cells. Iodixanol treatment increased the phosphorylation of p38, ERK and cleavage of caspase-3 in LLC-PK1 cells, which were significantly decreased by co-treatment with α-mangostin (2.5 and 5μM). The protective effect of α-mangostin on contrast-induced apoptotic damage was mediated by the inhibition of MAPKs and caspase activation.
