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Manganese and aging.

Nancy L Parmalee1, Michael Aschner1

  • 1Albert Einstein College of Medicine, Department of Molecular Pharmacology, 1300 Morris Park Avenue, Bronx, NY, United States.

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|June 14, 2016
PubMed
Summary
This summary is machine-generated.

Manganese (Mn) is essential but high doses cause manganism. This review explores how chronic, low-dose manganese exposure may impact aging mechanisms like neurogenesis and oxidative stress.

Keywords:
ManganeseManganismMicrogliaNeurodegenerationNeurogenesisOxidative stress

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Area of Science:

  • Environmental toxicology
  • Neuroscience
  • Aging research

Background:

  • Manganese (Mn) is an essential cofactor for enzymes, vital for biological function.
  • Abundant in nature and industry, Mn is ubiquitous in the environment and diet.
  • High Mn exposure causes manganism, a Parkinsonism-like neurodegenerative disorder.

Purpose of the Study:

  • To review the general effects of manganese exposure.
  • To investigate the potential relationship between chronic, subclinical manganese exposure and aging processes.
  • To focus on Mn's impact on neurogenesis, oxidative stress, and neuroinflammation.

Main Methods:

  • Literature review and synthesis of existing research on manganese toxicology and aging mechanisms.
  • Analysis of studies examining manganese's role in neurogenesis, oxidative stress, and microglial activation.
  • Examination of the link between environmental manganese exposure and age-related neurological changes.

Main Results:

  • Manganese is essential, but excessive exposure leads to irreversible neurological damage (manganism).
  • The effects of chronic, low-dose manganese exposure on aging are not well understood.
  • Manganese affects key cellular processes implicated in aging, including oxidative stress and neuroinflammation.

Conclusions:

  • Further research is needed to clarify the long-term health implications of chronic, low-level manganese exposure.
  • Manganese's influence on neurogenesis, oxidative stress, and neuroinflammation warrants investigation in the context of aging.
  • Understanding manganese's role in aging may inform public health strategies regarding environmental exposures.