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Related Concept Videos

Single-pass Transmembrane Proteins01:25

Single-pass Transmembrane Proteins

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Integral membrane proteins are tightly associated with the cell membrane and play a crucial role in cell communication, signaling, adhesion, and transport of the molecules. Some integral membrane proteins are present only in the membrane monolayer. For example, the enzyme fatty acid amide hydrolase is present in the cytoplasmic side of the membrane monolayer. In contrast, another type of integral membrane protein, also known as a transmembrane protein, spans across the membrane. Transmembrane...
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Multi-pass Transmembrane Proteins and β-barrels01:09

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In multi-pass transmembrane proteins, the polypeptide chain crosses the membrane more than once. The transmembrane polypeptide chain either forms an α-helix or β-strand structure. α-Helix containing multi-pass transmembrane proteins are ubiquitous, whereas β-strand containing ones are mainly found in gram-negative bacteria, mitochondria, and chloroplasts.
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Membrane Proteins01:30

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Plasma membranes have integral transmembrane proteins involved in facilitated transport. These proteins are collectively referred to as transport proteins, and they function as either channels for the material or as carriers themselves. Channel proteins have hydrophilic domains exposed to the intracellular and extracellular fluids and a hydrophilic channel through their core that provides a hydrated opening for solutes to pass through the membrane layers. Passage through the channel allows...
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Introduction to Membrane Proteins01:16

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The cell membrane, or plasma membrane, is an ever-changing landscape. It is described as a fluid mosaic where various macromolecules are embedded in the phospholipid bilayer. Among the macromolecules are proteins. The protein content varies across cell types. For example, mitochondrial inner membranes contain ~76% protein content, while myelin contains ~18% protein content. Individual cells contain many types of membrane proteins—red blood cells contain over 50—and different cell...
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Integral membrane proteins are proteins adhered to the lipid bilayer of a cell organelle or membrane. They can be of two types: transmembrane integral proteins that span the lipid bilayer and monotopic proteins that are attached to either side of the membrane but do not pass through it.
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Determining Membrane Protein Topology Using Fluorescence Protease Protection FPP
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Benchmark data for identifying multi-functional types of membrane proteins.

Shibiao Wan1, Man-Wai Mak1, Sun-Yuan Kung2

  • 1Department of Electronic and Information Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region.

Data in Brief
|June 14, 2016
PubMed
Summary
This summary is machine-generated.

This study introduces Mem-ADSVM, a novel predictor for identifying multi-functional membrane proteins. The provided data aids in training and testing this bioinformatics tool for enhanced proteomics research.

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Area of Science:

  • Proteomics
  • Bioinformatics
  • Computational Biology

Background:

  • Identifying membrane proteins and their functions is crucial in proteomics.
  • Classifying multi-functional membrane proteins presents significant bioinformatics challenges.

Purpose of the Study:

  • To present data for training and testing Mem-ADSVM.
  • To improve the prediction of multi-functional membrane protein types.

Main Methods:

  • Utilized a two-layer, multi-label prediction approach.
  • Employed Mem-ADSVM (Wan et al., 2016) for prediction.
  • Provided curated datasets for model evaluation.

Main Results:

  • The study offers data essential for validating Mem-ADSVM's performance.
  • Demonstrates the utility of Mem-ADSVM in membrane protein classification.

Conclusions:

  • Accurate identification of multi-functional membrane proteins is vital.
  • Mem-ADSVM offers a robust computational solution for this challenge.
  • The presented data facilitates further development and application in proteomics.