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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

310
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
305
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

310
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
310
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

796
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
796
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

324
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Related Experiment Video

Updated: Mar 19, 2026

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects
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Naturalistic speeding data: Drivers aged 75 years and older.

Anna Chevalier1, Aran John Chevalier2, Elizabeth Clarke3

  • 1The George Institute for Global Health, Sydney Medical School, The University of Sydney, GPO Box 5389, Sydney, NSW 2001, Australia.

Data in Brief
|June 14, 2016
PubMed
Summary

Older drivers

Keywords:
DeviceIn-vehicle monitoringNaturalisticOlder driversRoad safetySpeed

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Area of Science:

  • Gerontology
  • Transportation Safety
  • Traffic Engineering

Background:

  • Older drivers' speeding behavior is a critical aspect of road safety.
  • Understanding predictors of speeding in this demographic is essential for targeted interventions.
  • Previous research has explored various factors, but longitudinal naturalistic data is limited.

Purpose of the Study:

  • To investigate the predictors of speeding behavior in older drivers over a one-year period.
  • To analyze the influence of cognitive function, vision, functional decline, and driving history on speeding events.
  • To provide data for developing strategies to enhance road safety for elderly drivers.

Main Methods:

  • Naturalistic driving data collected over 52 weeks from drivers aged 75-94 years.
  • In-vehicle monitoring devices recorded Global Positioning System (GPS) data.
  • Speeding events defined as exceeding speed limits by 1 km/h (3% tolerance) over 30 seconds.

Main Results:

  • The dataset contains 124,374 speeding events.
  • Data processing and quality control methods are detailed.
  • This article focuses on the dataset's characteristics and preparation for analysis.

Conclusions:

  • The presented data enables longitudinal analysis of older drivers' speeding behavior.
  • Understanding these behaviors can inform safety policies and interventions.
  • Further research can utilize this dataset to explore the relationship between driver characteristics and speeding.