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Updated: Mar 19, 2026

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

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Signaling Networks Determining Life Span.

Celine E Riera^1,2,3, Carsten Merkwirth^1,2,3, C Daniel De Magalhaes Filho^2,4

¹Department of Molecular and Cell Biology, University of California, Berkeley, California 94720;

Annual Review of Biochemistry

|June 14, 2016

Summary

This summary is machine-generated.

Aging involves the breakdown of cellular balance, leading to damage and disease. Understanding conserved biological processes offers therapeutic strategies to extend healthy life span and prevent age-related illnesses.

Keywords:

DNA damage epigenetic regulation inflammation insulin-like signaling mammalian aging mitochondrial health nutrient sensing oxidative stress proteostasis telomere shortening

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Area of Science:

Molecular biology
Biochemistry
Gerontology

Background:

Organismal health relies on molecular and biochemical networks maintaining homeostasis.
Aging causes failure in homeostatic balance, leading to damage, tissue decline, and disease susceptibility.
Endogenous and environmental stresses accelerate aging.

Purpose of the Study:

To provide a comprehensive overview of evolutionarily conserved biological processes regulating aging.
To discuss the link between aging processes and disease prevention.
To explore therapeutic strategies for age-associated diseases based on aging mechanisms.

Main Methods:

Review of evolutionarily conserved biological processes.
Analysis of molecular and cellular signaling events in aging.
Literature synthesis on aging, disease, and lifespan extension.

Main Results:

Identified key molecular and cellular pathways controlling the aging rate.
Established connections between aging processes and the development of age-related diseases.
Highlighted the potential for interventions targeting these pathways.

Conclusions:

Understanding aging mechanisms is crucial for developing strategies against age-associated diseases.
Targeting conserved biological processes can prevent disease and extend healthy lifespan.
Interventions hold promise for improving healthspan and longevity.