Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Salivary Glands and Saliva

Salivary Glands and Saliva

The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...

Direct-Acting Cholinergic Agonists: Pharmacokinetics

Direct-Acting Cholinergic Agonists: Pharmacokinetics

Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...

Indirect-Acting Cholinergic Agonists: Pharmacokinetics

Indirect-Acting Cholinergic Agonists: Pharmacokinetics

Indirect-acting cholinergic agonists, or anticholinesterases, enhance the body's cholinergic activity by inhibiting acetylcholine's breakdown. They are categorized as reversible or irreversible agents based on their mechanism of action. They are further classified into short-acting, intermediate-acting, and long-acting agents based on their duration of action.
Reversible agents containing quaternary amines, such as neostigmine and edrophonium, are not easily absorbed orally because they...

Indirect-Acting Cholinergic Agonists: Mechanism of Action

Indirect-Acting Cholinergic Agonists: Mechanism of Action

Indirect-acting cholinergic agonists work by interacting with an enzyme called acetylcholinesterase (AChE) in the synaptic cleft. They can be reversible or irreversible inhibitors and have different effects on the enzyme.
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex,...

Cholinergic Antagonists: Pharmacokinetics

Cholinergic Antagonists: Pharmacokinetics

Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations, while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Remineralization and antimicrobial bioactivities of a Sn-CPP-ACFP nanocomplex.

Dental materials : official publication of the Academy of Dental Materials·2026

Same author

Cargo Secreted by the Type IX Secretion System of Porphyromonas gingivalis Are Tethered to O-Lipopolysaccharides via a Pentasaccharide Linker.

MicrobiologyOpen·2026

Same author

OmpA_C-Like Domain of PorE Is Essential for PorE Function in the Type IX Secretion System (T9SS) of Porphyromonas gingivalis and Some T9SS Cargo Proteins Are Secreted in a PorE-Independent Manner.

Microbiology and immunology·2025

Same author

Insights into type IX secretion from PorKN cogwheel structure bound to PorG and attachment complexes.

Nature communications·2025

Same author

Efficient enamel subsurface lesion remineralisation and dentine tubule occlusion by high concentration CPP-ACP: a randomised, cross-over in situ study.

Scientific reports·2025

Same author

PorA of the Type IX Secretion Is a Ligand of the PorXY Two-Component Regulatory System in Porphyromonas gingivalis.

Molecular microbiology·2025

Search research articles

Related Experiment Video

Updated: Mar 19, 2026

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry

Published on: August 7, 2012

The Interactions of CPP-ACP with Saliva.

Noorjahan Laila Huq¹, Helen Myroforidis², Keith J Cross³

¹Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Melbourne 3010, Australia. laila@unimelb.edu.au.

International Journal of Molecular Sciences

|June 14, 2016

Summary

This summary is machine-generated.

Casein phosphopeptide-stabilised amorphous calcium phosphate (CPP-ACP) complexes enhance dental remineralisation. These studies reveal CPP-ACP peptides interact with salivary pellicle proteins, localising CPP-ACP for improved tooth repair.

Keywords:

casein phosphopeptide enamel pellicle saliva

More Related Videos

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

Two-layered Membrane Sandwich Method for Laodelphax striatellus Saliva Collection

Two-layered Membrane Sandwich Method for Laodelphax striatellus Saliva Collection

Published on: August 27, 2021

Related Experiment Videos

Last Updated: Mar 19, 2026

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry

Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry

Published on: August 7, 2012

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

Two-layered Membrane Sandwich Method for Laodelphax striatellus Saliva Collection

Two-layered Membrane Sandwich Method for Laodelphax striatellus Saliva Collection

Published on: August 27, 2021

Area of Science:

Biomaterials Science
Dental Research
Nanotechnology

Background:

Early dental caries are repaired using remineralisation technology.
Casein phosphopeptide-stabilised amorphous calcium phosphate (CPP-ACP) complexes are key to this technology.
The interaction between CPP-ACP and the enamel salivary pellicle is not well understood.

Purpose of the Study:

To investigate the interaction between CPP-ACP complexes and the enamel salivary pellicle.
To elucidate the mechanism of CPP-ACP localisation on tooth surfaces.

Main Methods:

Analysis of interactions between CPP-ACP peptides and salivary proteins.
Characterisation of CPP-ACP localisation on enamel surfaces.

Main Results:

Predominant CPP-ACP peptides were found to interact with specific salivary proteins and peptides.
A mechanism for CPP-ACP localisation at the tooth surface was identified.

Conclusions:

CPP-ACP complexes interact with the enamel salivary pellicle.
This interaction facilitates the localisation of CPP-ACP, promoting remineralisation of early dental caries.