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Association between IGF2BP2 Polymorphisms and Type 2 Diabetes Mellitus: A Case-Control Study and Meta-Analysis
Ping Rao1, Hao Wang2, Honghong Fang3
1School of Public Health, Capital Medical University, Beijing 100069, China. raopingbj@126.com.
Summary
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) gene polymorphisms, specifically rs4402960 and rs1470579, are linked to type 2 diabetes mellitus (T2DM) risk in Asian populations. This study confirms the association, providing valuable insights into T2DM genetic susceptibility.
Area of Science:
- Genetics and Genomics
- Metabolic Diseases
- Population Health
Background:
- Genome-wide association studies (GWAS) identified associations between IGF2BP2 polymorphisms (rs4402960, rs1470579) and type 2 diabetes mellitus (T2DM) risk.
- Previous replication studies have reported inconsistent findings regarding this association.
Purpose of the Study:
- To investigate the genetic susceptibility of IGF2BP2 polymorphisms in relation to T2DM risk within a northern Han Chinese population.
- To conduct a meta-analysis to precisely evaluate the association between IGF2BP2 polymorphisms and T2DM risk in Asian populations.
Main Methods:
- A case-control study was performed with 461 T2DM patients and 434 healthy controls.
- A comprehensive meta-analysis was conducted, incorporating data from 36 previously published studies.
- Statistical analyses included genotype and allele comparisons, as well as dominant and recessive genetic models.
Main Results:
- The case-control study revealed that TT genotype at rs4402960 and CC genotype at rs1470579 were significantly associated with increased T2DM risk (p < 0.05).
- The meta-analysis confirmed that both rs4402960 and rs1470579 polymorphisms are associated with T2DM risk in Asians across various genetic models (p < 0.05).
- Stratification analysis indicated rs4402960 association remained significant, while rs1470579 results were less consistent across subgroups.
Conclusions:
- IGF2BP2 gene polymorphisms, rs4402960 and rs1470579, are significantly associated with T2DM risk in Asian populations.
- These findings contribute to understanding the genetic basis of T2DM and highlight potential targets for future research and prevention strategies.
