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Pregabalin concentrations in post-mortem blood-A two year study
Jane A Eastwood1, Elizabeth Davison1
1LGC, Toxicology Department, Queens Road, Teddington, Middlesex TW11 0LY, United Kingdom.
Forensic Science International
|June 14, 2016
Summary
This study analyzed post-mortem blood samples to establish reference ranges for pregabalin (PRG). Results indicate elevated PRG levels in many cases, with one fatality likely caused by PRG toxicity.
Area of Science:
- Forensic Toxicology
- Clinical Pharmacology
Background:
- Pregabalin (PRG) is widely prescribed for neuropathic pain, epilepsy, and anxiety.
- Limited data exists on therapeutic and fatal blood concentrations of PRG.
- Increasing evidence suggests pregabalin abuse and its role in fatalities.
Purpose of the Study:
- To review post-mortem blood concentrations of pregabalin (PRG).
- To establish likely therapeutic and fatal ranges for PRG.
- To investigate the role of PRG in post-mortem cases.
Main Methods:
- Analysis of 70 post-mortem blood samples for PRG concentrations.
- Review of cases between 2012 and 2014.
- Correlation of PRG levels with clinical findings and co-ingested substances.
Main Results:
- PRG detected in 70 post-mortem samples.
- 33% of cases showed PRG concentrations above the reference range (>17mg/L).
- PRG levels ranged from 0.05mg/L to 226mg/L (median 8.0mg/L); one death attributed to 76mg/L PRG.
Conclusions:
- The study provides crucial data on PRG blood concentrations in post-mortem cases.
- Elevated PRG levels are common, suggesting potential for toxicity and abuse.
- Multidrug use, especially with opioids, significantly increases fatal outcomes.
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