Related Experiment Video
Updated: Mar 19, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
Published on: May 10, 2018
Pharmacological Intervention in Type 2 Diabetes Mellitus - A Pathophysiologically Reasoned Approach?
Thomas Forst1, Tim Heise, Leona Plum-Morschel
1Profil Mainz GmbH & Co. KG, Malakoff Passage, Rheinstrasse 4C, 55116 Mainz, Germany. thomas.forst@profil.com.
Introduction:
In recent years, numerous pharmacological approaches for the treatment of type 2 diabetes mellitus (T2DM) have become available. While all of them have proven blood glucose-lowering effects, identifying the most beneficial drug or drug combination for the treatment of an individual patient has become an increasing challenge. Several guidelines attempt to provide decision criteria based on clinical characteristics and comorbidities in patients with T2DM, however, these guidelines still leave a broad range of capabilities for pharmacological treatment escalation. Pathophysiological Approach: Addressing the pathophysiology of T2DM might be a valuable approach for the selection and combination of different drugs that can provide the most comprehensive effects in the treatment of T2DM. Besides decreasing insulin sensitivity, a progressing imbalance in alpha and beta cell function of the Langerhans islet is a fundamental component in the complex pathophysiology of the disease.
Conclusion:
Considering the effect of different pharmacological interventions on the pathophysiological components in T2DM might be an effective tool guiding to most beneficial treatments, and may lead to a more tailored pharmacological intervention in patients with T2DM. .
Related Concept Videos
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Diabetes Mellitus: Type 2 and Gestational
Oral Hypoglycemic Agents: Biguanides and Glitazones
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Dipeptidyl Peptidase 4 Inhibitors
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...

