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Effects of ventricular conduction block patterns on mortality in hospitalized patients with dilated cardiomyopathy: a

Xiaoping Li1,2, Rong Luo3, Wei Fang4

  • 1Department of Cardiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Hospital of the University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China. lixiaoping0119@163.com.

BMC Cardiovascular Disorders
|June 15, 2016
PubMed

Insights

In dilated cardiomyopathy (DCM) patients, right bundle branch block (RBBB) and intraventricular conduction delays (IVCD) predict mortality, but left bundle branch block (LBBB) does not. These findings aid in risk stratification for DCM patients with ventricular conduction blocks.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Internal Medicine

Background:

  • Ventricular conduction blocks (VCBs) are linked to adverse outcomes in cardiac patients.
  • Prognostic significance of VCB patterns in dilated cardiomyopathy (DCM) requires further investigation.

Purpose of the Study:

  • To assess all-cause mortality in DCM patients with various VCB patterns.

Main Methods:

  • A cohort study of 1119 DCM patients with a median follow-up of 34.3 months.
  • Patients categorized into left bundle branch block (LBBB), right bundle branch block (RBBB), intraventricular conduction delays (IVCD), and narrow QRS groups.
  • All-cause mortality analyzed using Kaplan-Meier curves and Cox regression.

Main Results:

  • All-cause mortality rates were highest in IVCD (47.8%), followed by RBBB (32.9%), LBBB (27.1%), and narrow QRS (19.9%).
  • Significant differences in all-cause mortality risk observed between VCB and narrow QRS groups (P < 0.001).
  • RBBB, IVCD, elevated PASP, left atrium diameter, and NYHA class independently predicted mortality.

Conclusions:

  • RBBB and IVCD at admission are independent predictors of all-cause mortality in DCM patients.
  • LBBB was not found to be an independent predictor of mortality in this cohort.
Abstract

Keywords:
Dilated cardiomyopathyPrognosisPulmonary hypertensionSurvivalVentricular conduction block

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