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Related Experiment Videos

Exercise produces sensitivity to metocurine.

G A Gronert1, D A White, S L Shafer

  • 1Department of Anesthesiology, University of California, Davis 95616.

Anesthesiology
|June 1, 1989
PubMed
Summary
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Chronic exercise training increases skeletal muscle sensitivity to nondepolarizing muscle relaxants like metocurine (MTC). This finding suggests exercise may alter neuromuscular blockade response in patients.

Area of Science:

  • Pharmacology
  • Exercise Physiology
  • Neuromuscular Science

Background:

  • Chronic muscle disuse is known to decrease skeletal muscle sensitivity to nondepolarizing muscle relaxants.
  • Nondepolarizing muscle relaxants, such as metocurine (MTC), are commonly used in anesthesia.

Purpose of the Study:

  • To investigate whether chronic exercise conditioning could reverse the effects of disuse and increase skeletal muscle sensitivity to metocurine.
  • To determine the dose-response relationship of metocurine in exercised versus non-exercised dogs.

Main Methods:

  • Five dogs underwent a 5-week daily running exercise program.
  • A pharmacokinetic and pharmacodynamic study of metocurine was performed on exercised and control dogs.
  • Neuromuscular blockade was measured in the gastrocnemius muscles under anesthesia; plasma MTC concentrations were determined by radioimmunoassay.

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Main Results:

  • The concentration of metocurine required to produce 50% paralysis was significantly lower in exercised dogs (0.114 µg/mL) compared to non-exercised dogs (0.189 µg/mL).
  • The metocurine concentration-response curves were parallel between the two groups.
  • Exercise significantly increased skeletal muscle sensitivity to metocurine (P < 0.005).

Conclusions:

  • Chronic exercise conditioning increases skeletal muscle sensitivity to the nondepolarizing muscle relaxant metocurine.
  • These findings suggest that physical conditioning may alter the response to neuromuscular blocking agents.