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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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Affluence and Breast Cancer.

Steven Lehrer1, Sheryl Green1, Kenneth E Rosenzweig1

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|June 15, 2016
PubMed
Summary
This summary is machine-generated.

Higher income is linked to increased breast cancer incidence and better survival rates in White women, but not in other racial groups. This study explored the relationship between income, breast cancer, and survival across diverse US populations.

Keywords:
affluencebreast cancerincidenceincome

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Area of Science:

  • Oncology
  • Epidemiology
  • Health Economics

Background:

  • High income and socioeconomic status are associated with increased breast cancer incidence.
  • Previous studies assessed socioeconomic status using block-group measures; this study utilizes US Census income data.
  • Breast cancer risk factors like delayed childbirth and hormone supplement use are more prevalent in affluent women.

Purpose of the Study:

  • To investigate the relationship between socioeconomic status, using income data, and breast cancer incidence, prognostic markers, and survival.
  • To analyze disparities in breast cancer incidence and survival across different racial groups in relation to income.

Main Methods:

  • Utilized US state breast cancer incidence and mortality data (1999-2011) and median household income data (2010-2012).
  • Analyzed county-level breast cancer incidence and survival data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program (198 counties).
  • Employed multivariate general linear models to assess the effect of income and race on 5-year survival.

Main Results:

  • A significant positive correlation was found between income and breast cancer incidence in White women across 50 US states and the District of Columbia.
  • Income was significantly correlated with node involvement and 5-year relative survival in White women with localized breast cancer.
  • No significant correlation was observed between income and 5-year survival for Black or other racial groups; income did not significantly correlate with breast cancer incidence in men.

Conclusions:

  • Income is a significant factor in breast cancer incidence and survival, particularly for White women, suggesting socioeconomic disparities in cancer outcomes.
  • The study's hypothesis that higher income leads to better cancer care and survival is supported for White women but does not explain racial differences observed.
  • Further research is warranted to understand the complex interplay of income, race, and breast cancer outcomes, including genetic predispositions and access to care.