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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Related Experiment Video

Updated: Mar 19, 2026

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
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Could stem cells be the future therapy for sepsis?

S Manoj Kumar Kingsley1, B Vishnu Bhat1

  • 1Department of Neonatology, Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER), Puducherry 605006, India.

Blood Reviews
|June 15, 2016
PubMed
Summary

Stem cells offer promising therapeutic potential for sepsis, a condition with high mortality. Research explores how stem cells can mitigate sepsis's complex pathophysiology and prevent organ damage.

Keywords:
Multiple organ dysfunctionPathophysiologyPluripotencySepsisStem cellsTherapeutic intervention

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Area of Science:

  • Regenerative Medicine
  • Immunology
  • Critical Care Medicine

Background:

  • Sepsis remains a significant global health threat with persistently high mortality rates despite extensive research.
  • The complex pathophysiology of sepsis involves microbial infection, cytokine storm, endothelial dysfunction, coagulation, and immune paralysis, leading to multiple organ dysfunction.
  • Stem cells possess inherent properties like pluripotency and self-renewal, indicating their potential as therapeutic agents.

Purpose of the Study:

  • To explore the therapeutic potential of stem cells in treating sepsis.
  • To elucidate the mechanisms by which stem cells can counteract the multifaceted pathophysiology of sepsis.
  • To review the role of stem cells in preventing organ damage and improving organ function in sepsis.

Main Methods:

  • Review of existing literature on stem cell therapy and sepsis.
  • Analysis of the complex pathophysiological cascade of sepsis.
  • Discussion of stem cell mechanisms relevant to sepsis treatment.

Main Results:

  • Stem cells demonstrate the potential to modulate key steps in sepsis pathophysiology, including the cytokine storm and immune responses.
  • Evidence suggests stem cells can prevent or mitigate organ damage associated with sepsis.
  • Stem cell administration has shown promise in improving organ function in sepsis models.

Conclusions:

  • Stem cell therapy presents a viable strategy to address the high mortality and organ damage associated with sepsis.
  • Further research into optimal administration routes, dosages, and timing is crucial for maximizing stem cell efficacy in sepsis treatment.
  • Stem cells hold promise for altering the trajectory of sepsis by targeting its complex underlying mechanisms.