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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Related Experiment Video

Updated: Mar 19, 2026

Exploring the Application of Surface-enhanced Raman Scattering-based Biosensing of Individual sEVs in Disease Diagnosis and Therapeutics
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Exploring the Application of Surface-enhanced Raman Scattering-based Biosensing of Individual sEVs in Disease Diagnosis and Therapeutics

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Smart surface-enhanced Raman scattering traceable drug delivery systems.

Lei Liu1, Yonghong Tang, Sheng Dai

  • 1School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia. s.qiao@adelaide.edu.au s.dai@adelaide.edu.au.

Nanoscale
|June 15, 2016
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Summary

A new nanoparticle system tracks intracellular drug delivery using surface-enhanced Raman scattering (SERS). This advanced method offers higher sensitivity and resolution for observing non-fluorescent drug delivery in living cells.

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Pharmacology

Background:

  • Intracellular drug delivery requires precise tracking methods.
  • Current tracking techniques may lack sensitivity or resolution for certain drugs.
  • Nanoparticle-based systems offer potential for targeted delivery and tracking.

Purpose of the Study:

  • To develop a novel nanoparticle-based system for tracking intracellular drug delivery.
  • To utilize surface-enhanced Raman scattering (SERS) for enhanced signal detection.
  • To compare SERS tracing with conventional fluorescence methods.

Main Methods:

  • Development of gold@silica nanocarriers for drug delivery.
  • Incorporation of pH-cleavable covalent carboxylic hydrazone links for targeted release.
  • Utilizing SERS for non-destructive intracellular tracing of a model drug (doxorubicin).
  • Comparison of SERS with fluorescence tracing techniques.

Main Results:

  • The developed nanoparticle system demonstrated targeted cytotoxicity towards cancer cells.
  • SERS exhibited higher sensitivity and resolution compared to fluorescence tracing.
  • SERS enabled detailed observation of intracellular drug delivery dynamics.
  • The non-destructive nature of SERS was confirmed.

Conclusions:

  • The novel SERS-based nanoparticle system provides a sensitive and high-resolution method for tracking intracellular drug delivery.
  • This approach is particularly valuable for non-fluorescent drugs.
  • The system holds significant potential for studying drug delivery dynamics in living cells.