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Shock Wave Application to Cell Cultures

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Published on: April 8, 2014

Low-Energy Shockwave Therapy Improves Ischemic Kidney Microcirculation.

Xin Zhang¹, James D Krier¹, Carolina Amador Carrascal²

¹Division of Nephrology and Hypertension and.

Journal of the American Society of Nephrology : JASN

|June 15, 2016

Summary

Low-energy shockwave therapy improved kidney function and blood flow in pigs with renovascular disease. This noninvasive treatment restored microcirculation and may offer a new approach for managing renovascular hypertension.

Keywords:

chronic kidney disease kidney dysfunction renal artery stenosis

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Area of Science:

Cardiovascular and Renal Medicine
Regenerative Medicine
Biomedical Engineering

Background:

Microvascular rarefaction in renal artery stenosis contributes to kidney dysfunction and poor prognosis.
Low-energy shockwave therapy is known to promote angiogenesis, but its impact on kidney microvasculature in renovascular disease is not well understood.

Purpose of the Study:

To investigate the effects of low-energy shockwave therapy on restoring renal microcirculation and alleviating dysfunction in a porcine model of renovascular disease.

Main Methods:

Pigs with induced renal artery stenosis received six sessions of low-energy shockwave therapy over 3 weeks.
Evaluated blood pressure, urinary protein, renal blood flow, glomerular filtration rate, microvascular structure, and oxygenation.
Assessed expression of angiogenic factors and mechanotransducers ex vivo.

Main Results:

Shockwave therapy attenuated renovascular hypertension, normalized microvascular density and oxygenation in the stenotic kidney, and reduced fibrosis.
Improved renal function and microcirculation were observed in pigs with both 3- and 6-week stenotic periods.
No detectable kidney injury occurred in normal pigs treated with shockwave therapy.

Conclusions:

Low-energy shockwave therapy enhances stenotic kidney function and microcirculation, potentially via mechanotransduction-mediated pathways.
This therapy may serve as a novel, noninvasive intervention for managing renovascular disease and hypertension.