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Updated: Mar 19, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis, antimalarial properties and 2D-QSAR studies of novel triazole-quinine conjugates
Hassan M Faidallah1, Siva S Panda2, Juan C Serrano3
1Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Abstract:
Click chemistry technique led to novel 1,2,3-triazole-quinine conjugates 8a-g, 10a-o, 11a-h and 13 utilizing benzotriazole-mediated synthetic approach with excellent yields. Some of the synthesized analogs (11a, 11d-h) exhibited antimalarial properties against Plasmodium falciparum strain 3D7 with potency higher than that of quinine (standard reference used) through in vitro standard procedure bio-assay. Statistically significant BMLR-QSAR model describes the bio-properties, validates the observed biological observations and identifies the most important parameters governing bio-activity.
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