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Unifying the p73 knockout phenotypes: TAp73 orchestrates multiciliogenesis

Marco Napoli1, Elsa R Flores2

  • 1Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

Genes & Development
|June 15, 2016
PubMed
Summary

The transcription factor TAp73 dictates multiciliated cell differentiation, essential for epithelial function. This discovery explains the varied defects observed in p73 knockout mice, linking TAp73 to crucial developmental processes.

Keywords:
TAp73TP73airwayscentral transcriptional regulatormotile multiciliogenesisp73

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