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G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program

Frann Antignano1, Mitchell Braam2, Michael R Hughes2

  • 1The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada colby.zaph@monash.edu frann@brc.ubc.ca.

The Journal of Experimental Medicine
|June 15, 2016
PubMed
Summary

The study reveals the enzyme G9a is crucial for the development and function of group 2 innate lymphoid cells (ILC2s). Its absence impairs ILC2s, preventing allergic lung inflammation by repressing ILC3 genes.

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