Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

7.9K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
7.9K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

9.8K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
9.8K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-Specific 3D Printed Palatal Protection Plates for Le Fort III Osteotomy in Syndromic Midface Hypoplasia: What We Do.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same author

Live surgery in body donors with interactive digital technologies for innovative and interdisciplinary teaching of surgical anatomy.

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy·2026
Same author

Tribute to a patient, and to all patients.

Journal of hospital medicine·2026
Same author

<i>MYH9</i> Variant p.(Arg424Gly) Alters Nonmuscle Myosin IIA Contraction, Causing Atypical <i>MYH9</i>-related Disease.

Kidney international reports·2026
Same author

<i>ACTN4</i> p.Ile150Met Causes FSGS With Validation in Primary Fibroblasts and Immortalized Podocytes.

Kidney international reports·2026
Same author

Functional PET for mapping metabolic dynamics in Parkinson's disease.

Scientific reports·2025

Related Experiment Video

Updated: Jan 1, 2026

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis
09:20

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Published on: December 18, 2019

7.5K

Selenoprotein M is expressed during bone development.

Melanie Grosch1, Jennifer Fuchs1, Michael Bösl2

  • 1Institute of Human Genetics, University Hospital Erlangen, University of Erlangen-Nürnberg, Erlangen, Germany.

EXCLI Journal
|June 15, 2016
PubMed
Summary
This summary is machine-generated.

Selenoprotein M (SELM) is a selenium-containing protein found in the endoplasmic reticulum. This study shows SELM is prominently expressed in developing bones and tendons, suggesting a role in skeletal development.

Keywords:
Kashin-Beck osteoarthropathybone developmentseleniumselenoproteinsthiol-disulfide oxidoreductaseunfolded protein response

More Related Videos

Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone
10:03

Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone

Published on: May 10, 2019

13.2K
Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

12.4K

Related Experiment Videos

Last Updated: Jan 1, 2026

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis
09:20

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Published on: December 18, 2019

7.5K
Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone
10:03

Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone

Published on: May 10, 2019

13.2K
Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

12.4K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Developmental Biology

Background:

  • Twenty-five selenoproteins incorporating selenocysteine (Sec) have been identified.
  • Selenoprotein M (SELM) is an endoplasmic reticulum (ER)-resident protein potentially involved in protein processing and ER function.

Purpose of the Study:

  • Investigate the expression pattern and skeletal function of Selenoprotein M (SELM).
  • Determine SELM's role in bone development, given its overrepresentation in bone-specific expressed sequence tag (EST) libraries.

Main Methods:

  • RNA in situ hybridization was used to analyze Selm expression.
  • Expression was examined in chicken and mouse models at various developmental stages.

Main Results:

  • SELM exhibited prominent expression in bones, particularly in osteoblasts.
  • Significant expression was also observed in tendons.
  • Expression patterns suggest a role during bone development.

Conclusions:

  • SELM is expressed in key skeletal tissues during development.
  • The protein likely plays a role in the processing of secreted proteins within the skeletal system.