Related Experiment Video
Updated: Mar 19, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
[Complications in the treatment of ocular surface squamous neoplasia with interferon α‑2b in rheumatoid arthritis]
E Torres Suárez1, R Pinheiro2, N Schrage2
1Augenklinik, Krankenhaus Merheim, Kliniken der Stadt Köln, Ostmerheimer Str. 200, 51109, Köln, Deutschland. elenatorres@web.de.
Background:
Interferon α‑2b (IFN α‑2b) is an established and well-tolerated treatment for ocular surface squamous neoplasia (OSSN).
Method:
Report of complications in two patients with OSSN and rheumatoid arthritis treated with adjuvant topical IFN α‑2b.
Results:
One patient developed a scleral melt and the other one severe keratitis. After discontinuing treatment with IFN α‑2b both patients showed considerable improvement.
Conclusion:
Immunosuppressed patients with OSSN under topical IFN α‑2b should be closely monitored for early detection of complications.
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