Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:09

Cell Migration

19.1K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
19.1K
Cell Migration01:19

Cell Migration

7.3K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
7.3K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.7K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.7K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

6.1K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
6.1K
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

7.1K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
7.1K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

4.0K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase field crystal models with applications to laser deposition: A review.

Structural dynamics (Melville, N.Y.)·2024
Same author

A framework for reconstructing transmission networks in infectious diseases.

Applied network science·2022
Same author

The potential of urban distributed solar energy in transition economies: The case of Beirut city.

Journal of environmental management·2021
Same author

Machine learning for buildings' characterization and power-law recovery of urban metrics.

PloS one·2021
Same author

Kinetic roughening of the urban skyline.

Physical review. E·2020
Same author

Phase-field crystal for an antiferromagnet with elastic interactions.

Physical review. E·2019
Same journal

Erratum: Low-dimensional model for adaptive networks of spiking neurons [Phys. Rev. E 111, 014422 (2025)].

Physical review. E·2026
Same journal

Disentangling the effects of many-body forces on depletion interactions.

Physical review. E·2026
Same journal

Charge transport and mode transition in dual-energy electron beam diodes.

Physical review. E·2026
Same journal

Optimization of multisite reactions in complex compartmentalized media.

Physical review. E·2026
Same journal

Origin of geometric cohesion in nonconvex granular materials: Interplay between interdigitation and rotational constraints enhancing frictional stability.

Physical review. E·2026
Same journal

Interaction of walkers with a standing Faraday wave.

Physical review. E·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

9.1K

Phase-field model for collective cell migration.

Sara Najem1, Martin Grant2

  • 1Graduate Aerospace Laboratories (GALCIT), California Institute of Technology, Pasadena, California 91125, USA.

Physical Review. E
|June 15, 2016
PubMed
Summary
This summary is machine-generated.

This study introduces a phase-field model to simulate collective cell migration, revealing how cell behaviors influence tissue formation and dynamics. The model quantifies tissue surface tension and identifies a density threshold for cell-sheet formation.

More Related Videos

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.6K
Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.5K

Related Experiment Videos

Last Updated: Mar 19, 2026

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

9.1K
Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.6K
Study of Cell Migration in Microfabricated Channels
09:36

Study of Cell Migration in Microfabricated Channels

Published on: February 21, 2014

12.5K

Area of Science:

  • Biophysics
  • Computational Biology
  • Cellular Dynamics

Background:

  • Collective cell migration is crucial for development and disease.
  • Understanding the physical forces governing cell-cell interactions is essential.
  • Existing models often simplify cell behaviors and membrane dynamics.

Purpose of the Study:

  • To develop a phase-field model for collective cell migration.
  • To investigate the impact of cell morphology and membrane fluctuations on collective motion.
  • To quantify tissue surface tension and identify conditions for cell-sheet formation.

Main Methods:

  • Utilized a Ginzburg-Landau free-energy formulation for the phase-field model.
  • Incorporated models for adhesion, surface tension, repulsion, coattraction, and polarization.
  • Simulated cell morphologies and membrane fluctuations during collective migration.

Main Results:

  • Successfully modeled collective cell migration dynamics.
  • Quantified tissue surface tension as a function of individual cell cortical tension and adhesion.
  • Identified a critical density threshold for the formation of cell sheets.

Conclusions:

  • The phase-field model provides a robust framework for studying collective cell migration.
  • Cellular behaviors and physical properties significantly influence tissue-level dynamics.
  • The findings offer insights into tissue morphogenesis and the emergence of collective behaviors.