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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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[THE DEFEAT OF BONE TISSUE IN CHILDREN WITH INFLAMMATORY BOWEL DISEASES]

T V Gabrusskaya

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |June 16, 2016
    PubMed

    Insights

    Pediatric inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are linked to osteopenia and osteoporosis. This review addresses the critical issue of bone health in these young patients.

    Area of Science:

    • Pediatric Gastroenterology
    • Pediatric Endocrinology
    • Bone Metabolism

    Context:

    • Inflammatory bowel disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC).
    • Children with IBD face significant challenges in bone health.
    • Osteopenia and osteoporosis are prevalent complications in pediatric IBD.

    Purpose:

    • To review the current literature on osteopenia and osteoporosis in children with Crohn's disease and ulcerative colitis.
    • To highlight the prevalence, risk factors, and management strategies for bone loss in pediatric IBD.
    • To synthesize existing knowledge for clinical application and future research.

    Summary:

    • Children diagnosed with Crohn's disease or ulcerative colitis exhibit a higher incidence of osteopenia and osteoporosis.
    • Key contributing factors include chronic inflammation, malnutrition, corticosteroid use, and potentially genetic predispositions.
    • Early detection and intervention are crucial for mitigating long-term skeletal complications.

    Impact:

    • Informs pediatricians and gastroenterologists about the bone health risks associated with pediatric IBD.
    • Provides a foundation for developing targeted screening and treatment protocols.
    • Emphasizes the importance of a multidisciplinary approach to managing bone health in pediatric IBD patients.

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