Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Osteopenia in extremely low birthweight infants.

A Horsman1, S W Ryan, P J Congdon

  • 1Department of Medical Physics, General Infirmary, Leeds.

Archives of Disease in Childhood
|April 1, 1989
PubMed
Summary

Extremely low birthweight (ELBW) infants show significant growth in weight and length but lack bone mineral accretion by 39 weeks postconception. These ELBW infants exhibit substantial deficits in bone mineral content compared to full-term infants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of function of male-specific lethal 3 (Msl3) does not affect spermatogenesis in rodents.

Developmental dynamics : an official publication of the American Association of Anatomists·2023
Same author

Peptide gels of fully-defined composition and mechanics for probing cell-cell and cell-matrix interactions in vitro.

Matrix biology : journal of the International Society for Matrix Biology·2019
Same author

Assessment of nicotine uptake from cigarette smoke: comparison of a colorimetric test strip (NicCheck I™) and gas chromatography/mass selective detector.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2013
Same author

In vivo precision of the GE Lunar iDXA densitometer for the measurement of total body composition and fat distribution in adults.

European journal of clinical nutrition·2010
Same author

In vivo nicotine exposure in the zebra finch: a promising innovative animal model to use in neurodegenerative disorders related research.

Pharmacology, biochemistry, and behavior·2010
Same author

Validity of foot-to-foot bio-electrical impedance analysis body composition estimates in overweight and obese children.

International journal of body composition research·2010

Area of Science:

  • Neonatalogy
  • Pediatric Endocrinology
  • Growth and Development

Background:

  • Extremely low birthweight (ELBW) infants face challenges in achieving adequate growth and bone mineralization.
  • Understanding the long-term skeletal development of ELBW infants is crucial for optimizing their health outcomes.

Purpose of the Study:

  • To assess the growth and bone mineral content of extremely low birthweight (ELBW) infants.
  • To compare the physical and skeletal development of ELBW infants with full-term controls.

Main Methods:

  • Longitudinal study of 15 ELBW infants and 15 full-term controls.
  • Measurements included weight, crown-heel length, and forearm bone mineral content at birth, 8 weeks, and near 40 weeks postconception.
  • Statistical analysis to compare growth parameters and bone mineral deficits.

Related Experiment Videos

Main Results:

  • ELBW infants demonstrated catch-up growth in weight and length between 32 and 39 weeks postconception.
  • No significant bone mineral accretion was observed in ELBW infants during the study period.
  • At 39 weeks, ELBW infants were significantly lighter, shorter, and had a substantial bone mineral deficit compared to controls.

Conclusions:

  • ELBW infants experience catch-up growth but fail to achieve adequate bone mineralization by term-equivalent age.
  • Significant bone mineral deficits persist in ELBW infants, suggesting potential long-term skeletal health risks.
  • Further research is needed to investigate interventions to improve bone health in ELBW populations.