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Complete Myeloperoxidase Deficiency: Beware the "False-Positive" Dihydrorhodamine Oxidation
Ki Lee Milligan1, Daphne Mann2, Amy Rump2
1Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
The Journal of Pediatrics
|June 16, 2016
Abstract:
Myeloperoxidase deficiency is the most common inherited phagocyte disorder (1:2000) and causes an abnormal dihydrorhodamine oxidation test, which also is seen in chronic granulomatous disease. A patient with Candida meningitis and low dihydrorhodamine oxidation signal was diagnosed with chronic granulomatous disease but actually had compound heterozygous myeloperoxidase deficiency.
