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Blood Trace Element Concentrations in Polycystic Ovary Syndrome: Systematic Review and Meta-analysis
Poli Mara Spritzer1,2, Sheila Bünecker Lecke3,4, Vitor Costa Fabris3
1Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, 90035-003, Porto Alegre, RS, Brazil. spritzer@ufrgs.br.
Biological Trace Element Research
|June 16, 2016
Summary
This study found higher copper levels in women with Polycystic Ovary Syndrome (PCOS). Further research is needed to understand the link between trace elements and PCOS, a common condition affecting reproductive-aged women.
Area of Science:
- Endocrinology
- Nutritional Science
- Reproductive Medicine
Background:
- Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age.
- PCOS is characterized by hyperandrogenism, chronic anovulation, and is associated with inflammation and metabolic issues.
- Trace elements play roles in oxidative stress and inflammation, potentially influencing PCOS pathophysiology.
Purpose of the Study:
- To systematically review and meta-analyze existing evidence on trace element concentrations in women with PCOS.
- To investigate the association between specific trace elements and PCOS.
- To identify potential biomarkers or therapeutic targets related to trace element imbalances in PCOS.
Main Methods:
- Systematic search of MEDLINE and EMBASE databases for relevant studies published up to September 2015.
- Inclusion of case-control, cross-sectional, and cohort studies meeting the Rotterdam criteria for PCOS diagnosis.
- Random effects model meta-analysis of four selected studies involving 264 PCOS patients and 151 controls.
Main Results:
- Copper concentrations were significantly higher in women with PCOS compared to controls (mean difference 0.12 ppm).
- No significant differences in manganese or zinc levels were observed between PCOS patients and controls.
- Some studies reported no differences in chromium, cobalt, nickel, or vanadium, while one noted lower selenium in PCOS women.
Conclusions:
- The findings suggest a potential association between elevated copper levels and Polycystic Ovary Syndrome.
- Trace element dysregulation, particularly copper, may contribute to PCOS pathogenesis.
- Further research is warranted to elucidate the role of trace elements in PCOS and their clinical implications.
