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Buccal Dosage Forms: General Considerations for Pediatric Patients
Soledad Montero-Padilla1, Sitaram Velaga2, Javier O Morales3,4
1Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, 8380494, Santiago, Chile.
AAPS Pharmscitech
|June 16, 2016
Summary
Pediatric buccal drug delivery requires careful consideration of palatability and excipients. Novel dosage forms offer less invasive and more acceptable alternatives for children, improving therapy compliance.
Area of Science:
- Pharmaceutical Sciences
- Pediatric Pharmacology
- Drug Delivery Systems
Background:
- Pediatric drug biodistribution significantly differs from adults, necessitating specialized dosage forms.
- Buccal administration offers rapid systemic access via the buccal epithelium, enabling quick onset of action.
- Oral dosage forms for pediatric patients face stringent palatability requirements to enhance acceptance and compliance.
Purpose of the Study:
- To review the unique considerations for pediatric buccal drug delivery compared to adults.
- To explore novel dosage forms for pediatric buccal administration.
- To highlight the importance of excipient selection for pediatric palatability and efficacy.
Main Methods:
- Literature review focusing on pediatric buccal administration.
- Analysis of differences in drug biodistribution between pediatric and adult patients.
- Evaluation of various buccal dosage forms (tablets, lozenges, films, solutions) for pediatric suitability.
Main Results:
- Pediatric buccal administration requires specific attention to palatability and excipient properties.
- Novel dosage forms are being developed to improve pediatric acceptance and reduce invasiveness.
- Understanding excipient roles is crucial for effective and palatable pediatric buccal formulations.
Conclusions:
- Buccal drug delivery presents a promising route for pediatric patients, offering rapid absorption.
- Tailoring dosage forms and excipients to pediatric needs is essential for successful therapy.
- Further development of innovative buccal dosage forms can significantly improve pediatric medication adherence.
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