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Updated: Mar 19, 2026
An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
Endometrial Cancer and the Role of Lymphadenectomy
Leslie H Clark1, John T Soper2
1Clinical Fellow.
Importance:
The role of lymph node dissection in early-stage endometrial cancer is highly debated, but staging and prognosis are dependent on knowledge of lymph node metastasis.
Objective:
We sought to review the available data on the use of lymph node assessment in presumed early-stage endometrial cancer.
Evidence Acquisition:
A comprehensive literature review was performed using MEDLINE, the Cochrane Collaborative Database, and PubMed.
Results:
There is limited retrospective data that suggest a therapeutic benefit to lymphadenectomy. Prospective randomized trials have not shown a benefit to lymphadenectomy in low-risk patients, but found significant morbidity in patients undergoing lymphadenectomy. Selective lymph node assessment should be used in low-risk endometrial cancer. Sentinel lymph node assessment is emerging as a potential strategy for lymph node assessment.
Conclusions And Relevance:
Selective use of lymphadenectomy in early-stage endometrial cancer can reduce the morbidity associated with lymph node dissection without compromising clinical outcomes. Multiple strategies are available including sentinel lymph nodes and risk factor based lymphadenectomy.
