Effect of metoclopramide on gastric ulceration and secretion in albino rats

The antiulcer and antisecretory effects of metoclopramide were studied in aspirin-induced and pylorus-ligated gastric ulcers. The effects were compared with ranitidine (10 mg/kg, orally). The effect of propantheline alone and in combination with metoclopramide was studied against aspirin-induced gastric ulcers only. Metoclopramide (20 mg and 50 mg/kg) produced an ulcer protective effect both in aspirin-induced and pylorus-ligated experimental models. Its ulcer protective effect against aspirin-induced and pylorus-ligated gastric ulcers was comparable to ranitidine. Metoclopramide reduced the volume of gastric secretion but did not alter the total acidity; however, significant reduction in free acidity was noted. The ulcer protective effect of metoclopramide appeared to have multiple mechanisms like reduction in gastric secretion and free acidity, increased gastric emptying and cytoprotective action.