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Updated: Mar 19, 2026
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Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
Published on: December 8, 2023
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Paper-based Platform for Urinary Creatinine Detection.
Jarinya Sittiwong1, Fuangfa Unob
1Department of Chemistry, Faculty of Science, Chulalongkorn University.
Summary
A novel paper platform enables simple, visual colorimetric detection of creatinine. This method offers accurate, rapid creatinine analysis in urine, comparable to standard techniques.
Area of Science:
- Analytical Chemistry
- Materials Science
Background:
- Creatinine detection is crucial for assessing kidney function.
- Existing methods can be complex and time-consuming.
- A need exists for rapid, point-of-care diagnostic tools.
Purpose of the Study:
- To develop a novel paper-based platform for colorimetric creatinine detection.
- To evaluate the platform's performance against conventional methods.
Main Methods:
- Filter paper coated with 3-propylsulfonic acid trimethoxysilane.
- Ion-exchange mechanism for creatinine extraction.
- Jaffé reaction for colorimetric detection.
- Visual and quantitative color intensity analysis.
Main Results:
- Linear detection range of 10–60 mg L⁻¹ for creatinine.
- Detection limit of 4.2 mg L⁻¹.
- Comparable accuracy to the standard Jaffé method.
- Successful application in human urine samples.
Conclusions:
- The developed paper platform provides a simple, rapid, and accurate method for creatinine detection.
- This approach offers low reagent consumption and potential for point-of-care diagnostics.
- The method is suitable for analyzing creatinine in human urine samples.
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