Development of a Portable Surface Plasmon Resonance Sensor with Multi-Sensing Points Based on the Linear CCD Sensor

Area of Science:

• * Optical sensing technologies
• * Surface Plasmon Resonance (SPR) instrumentation

Background:

• * High-throughput analysis is crucial for environmental monitoring and clinical diagnostics.
• * Existing SPR sensors may lack the spatial resolution and portability required for diverse applications.

Purpose of the Study:

• * To develop a portable SPR sensor with an advanced optical system for multi-sensing.
• * To achieve high-throughput analysis with precise spatial resolution for various applications.

Main Methods:

• * Designed a portable SPR sensor incorporating a light-emitting diode, lenses, prism, polarizer, and a 2048-pixel linear CCD sensor.
• * Utilized a 6 mm sensor chip with a 30-stripe linear pattern (100 μm width/stripe) for multi-point detection.
• * Optimized SPR signal acquisition by adjusting CCD sensor position and averaging signals.

Main Results:

• * Successfully acquired SPR sensor signals from 30 distinct sensing points with 100 μm spatial resolution.
• * Achieved a low detection limit of approximately 3.2 - 5.5 × 10(-5) Refractive Index Units (RIU).
• * Demonstrated a standard deviation of ±4.5% in measurements by averaging signals from 6-7 CCD pixels per stripe.

Conclusions:

• * The developed portable SPR sensor facilitates high-throughput analysis with excellent spatial resolution.
• * The sensor is suitable for applications in environmental analysis and clinical diagnostics.
• * The novel optical system enhances the performance and applicability of SPR sensing.