Biosensors based on graphene oxide and its biomedical application

Area of Science:

• Materials Science
• Biotechnology
• Nanotechnology

Background:

• Graphene oxide (GO) is a promising material for biosensor development.
• GO possesses unique properties like water dispersibility and biocompatibility due to its structure.
• These properties enable high affinity for biomolecules and leverage graphene's characteristics.

Purpose of the Study:

• To classify and comprehensively review existing GO-based biological sensors.
• To analyze the role of GO in various sensing platforms.
• To provide insights into how GO enhances biosensing performance.

Main Methods:

• Classification of GO-based biosensors by signal generation strategy.
• Comprehensive literature review of GO-based sensing platforms.
• Analysis of GO's contribution to sensing mechanisms.

Main Results:

• GO-based biosensors utilize diverse strategies including FRET, LDI-MS, SERS, and electrochemical detection.
• The specific properties of GO are crucial for the functionality of these biosensors.
• GO significantly improves the sensitivity and specificity of biological detection.

Conclusions:

• Graphene oxide is a versatile platform for advanced biosensor design.
• Understanding GO's role is key to optimizing biosensing performance.
• This review provides a roadmap for future GO-based biosensor development.