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Updated: Mar 19, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Regulation of Myocardial Cell Growth and Death by the Hippo Pathway

Shohei Ikeda1, Junichi Sadoshima

  • 1Department of Cell Biology and Molecular Medicine, Rutgers - New Jersey Medical School.

Circulation Journal : Official Journal of the Japanese Circulation Society
|June 16, 2016
PubMed

Insights

The Hippo pathway, particularly Yes-associated protein (Yap), is crucial for cardiomyocyte survival and regeneration. Understanding its role offers new avenues for treating heart failure and promoting cardiac repair after injury.

Area of Science:

  • Cardiovascular Biology
  • Molecular Signaling
  • Regenerative Medicine

Background:

  • Heart failure results from cardiomyocyte loss, impacting clinical mortality.
  • Cardiomyocyte survival and regeneration are key therapeutic targets for heart failure.
  • The Hippo pathway regulates organ size by controlling apoptosis and proliferation.

Purpose of the Study:

  • To review the current understanding of the Hippo pathway's function in the heart.
  • To emphasize the specific role of Yes-associated protein (Yap) in cardiomyocyte growth and death.
  • To explore Yap's potential in promoting cardiac regeneration after myocardial infarction.

Main Methods:

  • Literature review of studies on the Hippo pathway and its components in cardiac research.
  • Analysis of evidence linking Yes-associated protein (Yap) to cardiomyocyte survival, proliferation, and hypertrophy.
  • Synthesis of findings on Yap's role in cardiac repair mechanisms.

Main Results:

  • The Hippo pathway, including Mst1/2, Lats1/2, and Yap, is present and active in the mammalian heart.
  • Yes-associated protein (Yap) is a critical downstream effector of the Hippo pathway in cardiomyocytes.
  • Evidence indicates Yap promotes cardiomyocyte survival and proliferation/hypertrophy, and facilitates cardiac regeneration.

Conclusions:

  • The Hippo pathway, especially Yap, plays a significant role in regulating cardiomyocyte homeostasis.
  • Targeting Yap may offer a therapeutic strategy to enhance cardiac repair and combat heart failure.
  • Further research into the Hippo pathway's cardiac functions is warranted for developing novel treatments.

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