Related Experiment Videos
[Synthesis and cytostatic action of 9-nitronoracronycine]
Archiv Der Pharmazie
|January 1, 1989
Abstract:
The synthesis of 9-nitronoracronycine (12) from 1,3-dihydroxy-10-methyl-7-nitroacridone (4) and 2-chlor-2-methyl-3-butyne is reported. Screening tests with the transplantation tumor leukemia P 388 proved 4 and 1-methoxy-10-methyl-7-nitroacridone (14) to be inactive. 12 and 3-methoxy-10-methyl-7-nitroacridone (15) showed cytotoxicity in higher doses. Structure-activity relationships are discussed.