Related Experiment Video
Updated: Mar 19, 2026
07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
13.1K
Recurrent Classical Type of Kaposi's Sarcoma Treated by Interferon-alpha
1Department of Dermatology, Kangnam St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Annals of Dermatology
|June 16, 2016
Summary
Classical Kaposi sarcoma (CKS) is a rare skin cancer. A patient with a history of CKS experienced complete resolution of a new lesion after interferon-alpha treatment, showing no recurrence for one year.
Area of Science:
- Oncology
- Dermatology
- Vascular Biology
Background:
- Kaposi sarcoma (KS) is a lympho-angioproliferative neoplasm with distinct clinical variants.
- Classical Kaposi sarcoma (CKS) typically presents as macules or plaques on the extremities.
Observation:
- A 60-year-old male presented with a solitary, asymptomatic patch on his left sole.
- The patient had a prior diagnosis and successful interferon-alpha treatment for CKS on his right sole three years earlier.
Findings:
- The patient received interferon-alpha (6 million units, three times weekly for 6 months) for the new lesion.
- The CKS lesion demonstrated complete resolution.
- No recurrence of the lesion was reported for one year post-treatment.
Implications:
- Interferon-alpha therapy can be effective for treating classical Kaposi sarcoma.
- Sustained remission is achievable with appropriate treatment for CKS.
- This case highlights the potential for successful management of recurrent CKS.
Related Concept Videos
01:30Inhibitors of Viral Protein Synthesis
1
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
1
01:10Retrovirus Life Cycles
50.4K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
50.4K
01:27Cytomegalovirus Disease
5
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
5
01:03Rous Sarcoma Virus (RSV) and Cancer
6.6K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.6K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.9K
5.9K
01:51Mechanisms of Retrovirus-induced Cancers
7.2K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.2K