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Related Concept Videos

Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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A Case of Dermatitis Neglecta.

You Jin Han1, So Young Kim1, Hae Young Choi1

  • 1Department of Dermatology, School of Medicine, Ewha Womans University, Seoul, Korea.

Annals of Dermatology
|June 16, 2016
PubMed
Summary
This summary is machine-generated.

Dermatitis neglecta, a skin condition mimicking psoriasis, is caused by poor hygiene. This case highlights its resolution with simple washing and provides the first histologic confirmation, aiding diagnosis and preventing unnecessary treatments.

Keywords:
Dermatitis neglectaUnwashed dermatosis

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Area of Science:

  • Dermatology
  • Histopathology

Background:

  • Dermatitis neglecta (unwashed dermatosis) is a clinical diagnosis characterized by pigmented, hyperkeratotic plaques resembling psoriasis.
  • It results from the accumulation of dirt and sebum due to inadequate hygiene in the affected skin areas.

Observation:

  • A 29-year-old male presented with an asymptomatic, hyperkeratotic, scaly plaque on his umbilicus, initially suspected as psoriasis.
  • During a skin biopsy procedure, the lesion was gently swabbed with hydrogen peroxide and saline gauze.
  • The patient's lesion completely cleared within 10 days post-procedure.

Findings:

  • Histologic examination revealed orthokeratotic hyperkeratosis and anastomosing rete ridges, consistent with dermatitis neglecta.
  • This case represents the first reported instance of dermatitis neglecta with accompanying histologic confirmation.
  • The characteristic histological features of dermatitis neglecta are described.

Implications:

  • Recognizing dermatitis neglecta is crucial to avoid misdiagnosis and unnecessary invasive procedures like skin biopsies.
  • Simple hygiene measures, such as regular washing, are effective treatments for dermatitis neglecta.
  • This report emphasizes the importance of considering clinical presentation and patient history in diagnosing skin conditions that mimic other dermatoses.