Related Experiment Video
Updated: Mar 19, 2026
06:15
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
2.0K
A Case of Acantholytic Squamous Cell Carcinoma
Ji Yeon Lim1, Mi Ok Do1, Seong Hyun Kim2
1Department of Dermatology, School of Medicine, Ewha Womans University, Seoul, Korea.
Annals of Dermatology
|June 16, 2016
Summary
Acantholytic squamous cell carcinoma, a variant of squamous cell cancer, presents as a nodule on sun-exposed skin. This case report details its unique histological features and presentation in an elderly patient.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Acantholytic squamous cell carcinoma (ASCC) is a rare variant of squamous cell carcinoma.
- It is characterized by pseudoglandular or tubular formations within the neoplastic proliferation.
Observation:
- ASCC typically presents as a nodule on sun-exposed skin in older individuals.
- Clinical features include scaling, crusting, and ulceration.
- Histologically, it shows epidermal-derived nests with focal or extensive loss of cell cohesion in glandular-like spaces.
Findings:
- The tumor cells are positive for EMA and cytokeratins.
- It is negative for dPAS, CEA, and mucicarmine, distinguishing it from eccrine neoplasms.
- This case report describes an 82-year-old woman with ASCC on her face.
Implications:
- Understanding the distinct histological and immunohistochemical profile of ASCC is crucial for accurate diagnosis.
- Differentiating ASCC from eccrine neoplasms is important for appropriate patient management.
- This case contributes to the literature on ASCC presentation and diagnosis.
More Related Videos
Related Concept Videos
01:30Skin Cancer
6.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.5K
01:29Classification of Epithelial Tissues: Stratified Epithelium
15.3K
Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
15.3K
01:29Staphylococcal Skin Infections
4
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
4
01:19Clinical Applications of Epidermal Stem Cells
3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K
01:24Cells of the Epidermis
8.8K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
8.8K
01:27Acne Infection
1
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
1