Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostaglandin E2 in pyloric stenosis.

G Goldman1, E Tiomny, P J Kahn

  • 1Department of Surgery "A", Ichilov Hospital, Tel-Aviv Medical Center, Israel.

Archives of Surgery (Chicago, Ill. : 1960)
|June 1, 1989
PubMed
Summary

Decreased prostaglandin E2 (PGE2) levels are linked to duodenal ulcer complications like pyloric stenosis. Lower PGE2 in active disease correlates with severity and irreversible damage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A retrospective cohort study comparing pregnancy outcomes and neonatal characteristics between HIV-infected and HIV-non-infected mothers.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2020
Same author

Evaluation of the reliability and validity of the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) in paediatric cutaneous lupus among paediatric dermatologists and rheumatologists.

The British journal of dermatology·2018
Same author

Corrigendum: methotrexate in chronic active Crohn's disease: a double-blind, randomized, israeli multicenter trial.

The American journal of gastroenterology·2015
Same author

Calciotrophic hormones and hyperglycemia modulate vitamin D receptor and 25 hydroxyy vitamin D 1-α hydroxylase mRNA expression in human vascular smooth muscle cells.

The Journal of steroid biochemistry and molecular biology·2014
Same author

New vitamin D less-calcemic analog affect human bone cell line and cultured vascular smooth muscle cells similar to other less-calcemic analogs.

The Journal of steroid biochemistry and molecular biology·2013
Same author

Effects of commonly used medications on bone tissue mineralisation in SaOS-2 human bone cell line: an in vitro study.

The bone & joint journal·2013

Area of Science:

  • Gastroenterology
  • Peptic Ulcer Disease Pathogenesis
  • Prostaglandin Biology

Background:

  • Prostaglandins, particularly prostaglandin E2 (PGE2), are recognized for cytoprotective functions in the gastroduodenal mucosa.
  • Reduced PGE2 levels are implicated in duodenal ulcer pathogenesis, potentially impairing gastric motility and enhancing obstructive changes.

Purpose of the Study:

  • To investigate the hypothesis that decreased prostaglandin E2 (PGE2) levels contribute to the development and severity of pyloric stenosis in patients with duodenal ulcers.
  • To establish a correlation between PGE2 levels and the clinical/endoscopic findings in active pyloric stenosis.

Main Methods:

  • Seventeen patients with duodenal ulcers and pyloric stenosis underwent endoscopic evaluation.
  • Biopsy specimens were collected from various gastroduodenal sites, and gastric secretions were analyzed for PGE2 levels.

Related Experiment Videos

  • PGE2 levels were compared between the active phase of stenosis and a later quiescent or exacerbated phase.

    • Main Results:

    • Statistically significant decreases in PGE2 levels were observed in gastroduodenal tissues and secretions during the active phase of pyloric stenosis compared to convalescence.
    • A direct correlation was found between the severity of clinical and endoscopic findings and the measured PGE2 levels.
    • Further reductions in PGE2 during a second endoscopy indicated the presence of scar tissue, suggesting irreversible disease.

    Conclusions:

    • Decreased prostaglandin E2 (PGE2) levels are significantly associated with the active phase of pyloric stenosis in duodenal ulcer patients.
    • PGE2 levels serve as a potential biomarker for disease severity and progression towards irreversible obstructive peptic disease.
    • Restoration of PGE2 levels may be a therapeutic target for managing duodenal ulcer complications.