Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Receptors: Overview01:22

Opioid Receptors: Overview

6.1K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
6.1K
Cholinergic Receptors: Muscarinic01:25

Cholinergic Receptors: Muscarinic

5.8K
The pharmacological actions of acetylcholine are elicited via its binding to two families of cholinergic receptors or cholinoceptors, namely, muscarinic and nicotinic receptors. Muscarinic receptors are G protein-coupled receptors and have five subtypes, M1–M5. All mAChR subtypes are activated by acetylcholine and blocked by the antagonist, atropine. 
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+....
5.8K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

3.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
3.0K
Adrenergic Receptors (Adrenoceptors): Classification01:27

Adrenergic Receptors (Adrenoceptors): Classification

5.5K
Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
5.5K
Regulation of Food Intake01:30

Regulation of Food Intake

3.1K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.1K
The Two-State Receptor Model01:29

The Two-State Receptor Model

3.4K
The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to induce or inhibit a biological response. When no natural ligands are present, a receptor exists in an equilibrium of inactive (Ri) and active (Ra) conformations. The inactive form does not produce a response, while the active form generates a basal effect known as constitutive activity.
The binding affinity of a drug determines its interaction with...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unilateral Optic Disc Edema in the Setting of Contralateral Intravitreal Anti-VEGF Injections as the presenting finding in POEMS Syndrome.

Journal of vitreoretinal diseases·2026
Same author

Perceptions of Prognosis and Hope Among Patients With Advanced Cancer at the Time of Enrollment in an Early-Phase Clinical Trial.

JCO oncology practice·2026
Same author

The receipt of psychological services and acceptability of local follow-up care for childhood cancer survivors: are there rural vs. urban differences?

Journal of cancer survivorship : research and practice·2026
Same author

Characterization of p53 p.T253I as a pathogenic mutation underlying Li-Fraumeni Syndrome.

PloS one·2025
Same author

Pilot Feasibility Trial of a Supportive Care Digital Application for Patients with Advanced Nonsmall Cell Lung Cancer.

Journal of palliative medicine·2025
Same author

Racial and Rural Disparities in Financial Toxicity and Healthcare Transitions Among Adolescent and Young Adult Cancer Survivors in Kentucky: A Cross-Sectional Study.

Cancer control : journal of the Moffitt Cancer Center·2025
Same journal

Enhancing cereal productivity via nitrogen use efficiency: from conventional breeding to modern genomics.

Frontiers in genetics·2026
Same journal

Transcriptomic analysis reveals FcγR-mediated phagocytosis as a key pathway for the anti-inflammatory action of <i>Polygonatum sibiricum</i> polysaccharides in loach.

Frontiers in genetics·2026
Same journal

A novel <i>ABO</i> splice site variant underlying the A<sub>3</sub> phenotype: immunogenetic basis and functional dissection.

Frontiers in genetics·2026
Same journal

Case Report: Identification of two novel <i>ALMS1</i> variants in a patient with a ciliopathy resembling Alström syndrome.

Frontiers in genetics·2026
Same journal

Integrative analysis identifies Hspa5 as a key regulator of the ERS/UPR-immune axis in spinal cord injury.

Frontiers in genetics·2026
Same journal

Evaluation of genomic selection to improve survival of eastern oysters infected with <i>Perkinsus marinus</i>.

Frontiers in genetics·2026
See all related articles

Related Experiment Video

Updated: Mar 19, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.9K

Melanocortin 1 Receptor: Structure, Function, and Regulation.

Erin M Wolf Horrell1, Mary C Boulanger2, John A D'Orazio3

  • 1Department of Physiology, University of Kentucky College of Medicine Lexington, KY, USA.

Frontiers in Genetics
|June 16, 2016
PubMed
Summary
This summary is machine-generated.

The melanocortin 1 receptor (MC1R) influences skin

Keywords:
ASIPATRDNA repairMC1RmelanocortinmelanocytemelanomaβD3

More Related Videos

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

8.0K
Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

17.4K

Related Experiment Videos

Last Updated: Mar 19, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.9K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

8.0K
Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

17.4K

Area of Science:

  • Genetics and Molecular Biology
  • Dermatology
  • Cancer Research

Background:

  • The melanocortin 1 receptor (MC1R) is a key regulator of skin pigmentation and UV response.
  • MC1R genetic variations are linked to skin sensitivity, pigmentation, and melanoma risk.
  • MC1R signaling impacts DNA repair pathways crucial for genomic stability.

Purpose of the Study:

  • To review the structure and function of MC1R.
  • To summarize laboratory findings on how MC1R signaling affects DNA repair.
  • To elucidate the molecular mechanisms linking MC1R to genomic stability.

Main Methods:

  • Review of existing literature on MC1R structure and function.
  • Summary of experimental findings from the authors' laboratory.
  • Analysis of molecular pathways involving MC1R, cAMP, and nucleotide excision repair (NER).

Main Results:

  • MC1R signaling, via cAMP, enhances melanin production and deposition in the epidermis.
  • Activated MC1R signaling boosts nucleotide excision repair (NER) efficiency.
  • Defective MC1R function leads to impaired melanization and reduced DNA repair capacity.

Conclusions:

  • MC1R plays a critical role in skin's defense against UV radiation through pigmentation and DNA repair.
  • Understanding MC1R's impact on NER is vital for comprehending melanoma risk.
  • MC1R signaling modulation may offer therapeutic strategies for UV-related skin damage and cancer prevention.