Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Expression levels of <i>EPHB4, EFNB2</i> and caspase-8 are associated with clinicopathological features and progression of esophageal squamous cell cancer.

Oncology letters·2019

Same author

Circulating osteocalcin: A potential predictor of ketosis in type 2 diabetes.

Diabetes/metabolism research and reviews·2019

Same author

Provincial and sector-level material footprints in China.

Proceedings of the National Academy of Sciences of the United States of America·2019

Same author

Functionalized selenium nanoparticles for targeted siRNA delivery silence Derlin1 and promote antitumor efficacy against cervical cancer.

Drug delivery·2019

Same author

Long non-coding RNA RNCR3 promotes glioma progression involving the Akt/GSK-3β pathway.

Oncology letters·2019

Same author

Doxorubicin-loaded functionalized selenium nanoparticles for enhanced antitumor efficacy in cervical carcinoma therapy.

Materials science & engineering. C, Materials for biological applications·2019

Search research articles

Related Experiment Video

Updated: Mar 19, 2026

Retroviral CRISPR/Cas9-Mediated Gene Targeting for the Study of Th17 Differentiation in Vitro

Retroviral CRISPR/Cas9-Mediated Gene Targeting for the Study of Th17 Differentiation in Vitro

Published on: November 15, 2024

Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy.

Taslima T Lina¹, Tierra Farris¹, Tian Luo¹

¹Department of Pathology, University of Texas Medical Branch Galveston, TX, USA.

Frontiers in Cellular and Infection Microbiology

|June 16, 2016

Summary

Ehrlichia chaffeensis, a bacterium causing human monocytotropic ehrlichiosis (HME), reprograms host cells for survival. This review explores its molecular strategies for intracellular infection and evading defenses.

Keywords:

Ehrlichia chaffeensis cell signaling epigenetics innate immune response post translational modification (PTM)secretion system tandem repeat proteins (TRPs)

More Related Videos

Highly Efficient Transfection of Human THP-1 Macrophages by Nucleofection

Highly Efficient Transfection of Human THP-1 Macrophages by Nucleofection

Published on: September 2, 2014

Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis

Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis

Published on: January 2, 2017

Related Experiment Videos

Last Updated: Mar 19, 2026

Retroviral CRISPR/Cas9-Mediated Gene Targeting for the Study of Th17 Differentiation in Vitro

Retroviral CRISPR/Cas9-Mediated Gene Targeting for the Study of Th17 Differentiation in Vitro

Published on: November 15, 2024

Highly Efficient Transfection of Human THP-1 Macrophages by Nucleofection

Highly Efficient Transfection of Human THP-1 Macrophages by Nucleofection

Published on: September 2, 2014

Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis

Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis

Published on: January 2, 2017

Area of Science:

Microbiology
Infectious Diseases
Cell Biology

Background:

Ehrlichia chaffeensis is an obligate intracellular bacterium responsible for human monocytotropic ehrlichiosis (HME).
HME is an emerging, potentially fatal, tick-borne zoonotic disease.
The bacterium preferentially infects mononuclear phagocytes, but mechanisms of infection and immune evasion are poorly understood.

Purpose of the Study:

To review recent advances in understanding Ehrlichia chaffeensis's molecular and cellular mechanisms.
To elucidate how E. chaffeensis reprograms host cells for intracellular survival.
To highlight the role of effector proteins in host-pathogen interactions.

Main Methods:

This is a review article, synthesizing existing research.
Focuses on molecular and cellular mechanisms.
Examines host-pathogen interactions, particularly involving effector proteins.

Main Results:

E. chaffeensis employs effector proteins with tandem and ankyrin repeats.
These proteins are crucial for host cellular reprogramming.
The bacterium manipulates host cell processes to establish and maintain intracellular infection.

Conclusions:

Understanding E. chaffeensis's strategies is key to combating HME.
Effector proteins play a significant role in host cell manipulation.
Further research into these mechanisms can inform therapeutic strategies.