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Remote Laboratory Management: Respiratory Virus Diagnostics
Published on: April 6, 2019
Acute viral bronchiolitis in South Africa: Diagnostic flow
Insights
Bronchiolitis in young children is diagnosed using clinical signs like wheezing and hyperinflation. Severe cases may require hospitalization, with risk factors including prematurity and congenital heart or lung conditions.
Area of Science:
- Pediatrics
- Respiratory Medicine
Background:
- Bronchiolitis is a common viral lower respiratory tract infection in infants and young children.
- Diagnosis is primarily clinical, based on characteristic signs and symptoms.
Purpose of the Study:
- To outline the clinical diagnosis, severity assessment, and management of bronchiolitis.
- To highlight key clinical indicators and risk factors for severe disease.
Main Methods:
- Clinical observation and assessment of signs and symptoms.
- Measurement of peripheral arterial oxygen saturation.
- Identification of risk factors for severe disease.
Main Results:
- Diagnosis relies on wheezing, hyperinflation, and upper respiratory prodrome.
- Hyperinflation is a key indicator, with signs like Hoover sign present in severe cases.
- Oxygen saturation <92% (sea level) or <90% (inland) indicates need for hospitalization.
Conclusions:
- Bronchiolitis diagnosis is clinical; imaging and blood tests are generally not required.
- Prompt recognition of severe signs and risk factors is crucial for timely intervention.
- Management focuses on supportive care and oxygen therapy when indicated.
Abstract:
Bronchiolitis may be diagnosed on the basis of clinical signs and symptoms. In a young child, the diagnosis can be made on the clinical pattern of wheezing and hyperinflation. Clinical symptoms and signs typically start with an upper respiratory prodrome, including rhinorrhoea, low-grade fever, cough and poor feeding, followed 1 - 2 days later by tachypnoea, hyperinflation and wheeze as a consequence of airway inflammation and air trapping.The illness is generally self limiting, but may become more severe and include signs such as grunting, nasal flaring, subcostal chest wall retractions and hypoxaemia. The most reliable clinical feature of bronchiolitis is hyperinflation of the chest, evident by loss of cardiacdullness on percussion, an upper border of the liver pushed down to below the 6th intercostal space, and the presence of a Hoover sign(subcostal recession, which occurs when a flattened diaphragm pulls laterally against the lower chest wall).Measurement of peripheral arterial oxygen saturation is useful to indicate the need for supplemental oxygen. A saturation of <92% at sea level and 90% inland indicates that the child has to be admitted to hospital for supplemental oxygen. Chest radiographs are generally unhelpful and not required in children with a clear clinical diagnosis of bronchiolitis.Blood tests are not needed routinely. Complete blood count tests have not been shown to be useful in diagnosing bronchiolitis or guiding its therapy. Routine measurement of C-reactive protein does not aid in management and nasopharyngeal aspirates are not usually done.Viral testing adds little to routine management. Risk factors in patients with severe bronchiolitis that require hospitalisation and may even cause death, include prematurity, congenital heart disease and congenital lung malformations.
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