Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An experimental study of vancomycin-induced cochlear damage.

R A Tange1, H L Kieviet, J von Marle

  • 1Department of Otorhinolaryngology, Academisch Medisch Centrum, Universiteit van Amsterdam, The Netherlands.

Archives of Oto-Rhino-Laryngology
|January 1, 1989
PubMed
Summary

This study investigated vancomycin

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How I do it: modified Todd's meatoplasty.

The Journal of laryngology and otology·2016
Same author

[Rectal neuroendocrine tumors: endoscopic therapy].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2016
Same author

Comparison of two cochlear implantation techniques and their effects on the preservation of residual hearing. Is the surgical approach of any importance?

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2013
Same author

What to do with the other ear after cochlear implantation.

Cochlear implants international·2008
Same author

Audiometric patterns in ototoxicity of intra-arterial Cisplatin chemoradiation in patients with locally advanced head and neck cancer.

Audiology & neuro-otology·2006
Same author

How we do it: Reinsertion of the stylet into the nucleus contour cochlear implant to facilitate second insertion. A helpful technique salvaging the cochlear implant device.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2006

Area of Science:

  • Ototoxic effects of antibiotics
  • Pharmacology and toxicology
  • Auditory system research

Background:

  • Vancomycin is a widely used antibiotic.
  • Conflicting reports exist regarding its ototoxicity.
  • Previous studies have yielded inconclusive results on vancomycin's impact on hearing.

Purpose of the Study:

  • To experimentally assess the ototoxic effects of vancomycin.
  • To investigate potential hearing damage associated with vancomycin treatment.
  • To clarify the safety profile of vancomycin concerning auditory function.

Main Methods:

  • Utilized a Mongolian gerbil animal model.
  • Administered vancomycin intraperitoneally at 80 mg/kg/day for two weeks.
  • Evaluated hearing using evoked response audiometry before and after treatment.
  • Conducted post-mortem cochlear analysis via scanning electron microscopy and microdissection with hair cell counting.

Main Results:

  • No clear evidence of ototoxicity was observed in gerbils treated with vancomycin.
  • Auditory function remained unaffected in the experimental group.
  • Cochlear hair cell counts showed no significant damage attributable to vancomycin.

Conclusions:

  • Vancomycin, at the tested dosage and duration, does not appear to cause ototoxicity in this animal model.
  • The findings suggest vancomycin may be safe concerning auditory health.
  • Further research may be warranted to confirm these ototoxicity findings in diverse models.

Related Experiment Videos