Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

344
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
344
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

310
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
310
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

305
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
305
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

324
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
324
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

310
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
310
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

57
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
57

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detection of Mild COVID-19 in Frail Older Adults Using Simple Inflammatory Indices: A Comparative Cohort Analysis.

Life (Basel, Switzerland)·2025
Same author

Complications, Blood Transfusion Prediction, and Long-Term Survival in Elderly Patients with Pubic Rami Fractures.

Clinical interventions in aging·2025
Same author

Inhibition of α4β1 Integrin Activity by Small Tellurium Compounds Regulates PD-L1 Expression and Enhances Antitumor Effects.

International journal of biological sciences·2024
Same author

Gastric cancer risk in the elderly is associated with omeprazole use and inversely associated with aspirin use.

European journal of gastroenterology & hepatology·2023
Same author

Different effects of chronic omeprazole use on osteoporotic fractures rate in the elderly.

British journal of clinical pharmacology·2023
Same author

Informal caregivers' negative affect: The interplay of caregivers' resilience, aging anxiety and burden.

Aging & mental health·2022

Related Experiment Video

Updated: Mar 19, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

10.8K

Does Polypharmacy in Nursing Homes Affect Long-Term Mortality?

Agata Schlesinger1,2, Avraham Weiss1,2, Olga Nenaydenko3

  • 1Department of Geriatrics, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.

Journal of the American Geriatrics Society
|June 16, 2016
PubMed
Summary

Polypharmacy, the use of multiple medications, did not increase mortality risk in nursing home residents. This study found no significant association between the number of drugs taken and 2-year mortality rates.

Keywords:
elderlynursing homepolypharmacysurvival

Related Experiment Videos

Last Updated: Mar 19, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

10.8K

Area of Science:

  • Gerontology
  • Clinical Pharmacy
  • Public Health

Background:

  • Polypharmacy is common in nursing home residents, increasing the risk of adverse drug events and healthcare costs.
  • Understanding the association between polypharmacy and mortality is crucial for optimizing medication management in this vulnerable population.

Purpose of the Study:

  • To investigate the association between polypharmacy and mortality in nursing home residents.
  • To identify factors associated with increased or decreased mortality in this population.

Main Methods:

  • Prospective observational cohort study involving 764 nursing home residents in central Israel.
  • Two-year mortality was assessed and correlated with the number of medications taken at baseline, controlling for confounders.
  • Data included demographics, comorbidities, and medication use.

Main Results:

  • Polypharmacy, defined by the number of drugs, was not significantly associated with a two-year increased risk of mortality.
  • Factors independently associated with higher mortality included male sex, older age, higher comorbidity index, and use of anticoagulant or antihyperglycemic medications.
  • Factors associated with lower mortality included higher body mass index and use of lipid-lowering or selective serotonin reuptake inhibitor/serotonin-norepinephrine reuptake inhibitor medications.

Conclusions:

  • Quantitative polypharmacy was not associated with increased mortality in nursing home residents.
  • Specific medications and patient characteristics, rather than the sheer number of drugs, appear to be more influential on mortality outcomes.