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Updated: Mar 19, 2026

Optimization of Crystal Growth for Neutron Macromolecular Crystallography
Published on: March 13, 2021
Isoconversional Kinetics of Nonisothermal Crystallization of Salts from Solutions
Victoria L Stanford1, Calla M McCulley1, Sergey Vyazovkin1
1Department of Chemistry, University of Alabama at Birmingham , 901 South 14th Street, Birmingham, Alabama 35294, United States.
Abstract:
In this study, differential scanning calorimetry (DSC) has been applied to measure the kinetics of nonisothermal crystallization of potassium nitrate and ammonium perchlorate from unsaturated and saturated aqueous solutions. DSC data have been analyzed by an advanced isoconversional method that demonstrates that the process is represented by negative values of the effective activation energy, which varies with the progress of crystallization. The classical nucleation model can be used to predict and understand the experimentally observed variation in the effective activation energy. The saturated and unsaturated solutions have demonstrated distinctly different crystallization kinetics. It is suggested that the unsaturated solutions undergo a change in crystallization mechanism from homogeneous to heterogeneous nucleation.
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