Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

1
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
1
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

1
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
1
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

775
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
775
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

22
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
22
Development of Human Microbiota01:30

Development of Human Microbiota

5
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
5
The Oral Microbiota01:27

The Oral Microbiota

7
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
7

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic Value and Treatment Responsiveness of Ultrasonography Features in Correlation With Clinical Findings in Early Peripheral Spondyloarthritis.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Preventing MALT1-mediated CYLD cleavage induces intestinal dysbiosis and reduces EAE severity.

EMBO reports·2026
Same author

Repeated dosing of myrrh, chamomile extract, and coffee charcoal reveals potential health-beneficial effects in patients with irritable bowel syndrome in the M-SHIME simulator.

PloS one·2026
Same author

Structural and mechanistic insights into the constitutive Themis-Grb2 complex in T cell signalling.

Nature communications·2026
Same author

Probiotic detoxification of heavy metals: functional assessment in simulated intestinal and <i>ex vivo</i> models.

Frontiers in microbiology·2026
Same author

Acute pulmonary histoplasmosis in a Belgian traveller returning from Suriname diagnosed with NGS: a case report.

Diagnostic microbiology and infectious disease·2026

Related Experiment Video

Updated: Mar 19, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.5K

How the microbiota shapes rheumatic diseases.

Tom Van de Wiele1, Jens T Van Praet2,3,4, Massimo Marzorati1

  • 1Laboratory of Microbial Ecology and Technology (LabMET), Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, Ghent, B-9000, Belgium.

Nature Reviews. Rheumatology
|June 17, 2016
PubMed
Summary

The gut microbiota influences immune responses and barrier function, impacting rheumatic diseases. Promoting gut health may offer new strategies for preventing or treating these conditions.

More Related Videos

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.4K
Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.6K

Related Experiment Videos

Last Updated: Mar 19, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.5K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.4K
Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.6K

Area of Science:

  • Microbiology
  • Immunology
  • Rheumatology

Background:

  • The human gut hosts a diverse microbial community crucial for health.
  • Mucosal interfaces are key sites for microorganism-host interactions.
  • Gut microbiota influences mucosal barrier integrity and immune function.

Purpose of the Study:

  • To review the gut microbiota's role in local and systemic immunity.
  • To explore how gut microbiota disturbances affect rheumatic diseases.
  • To identify potential therapeutic strategies targeting host-microorganism homeostasis.

Main Methods:

  • Literature review of studies on gut microbiota and immune responses.
  • Analysis of the impact of microbiota dysbiosis on rheumatic disease development.
  • Synthesis of current knowledge on host-microorganism interactions in health and disease.

Main Results:

  • Gut microbiota composition and function are linked to immune system modulation.
  • Alterations in the gut microbiota can influence inflammatory and anti-inflammatory processes.
  • Microbiota dysbiosis is implicated in the pathogenesis and progression of rheumatic diseases.

Conclusions:

  • The gut microbiota plays a significant role in shaping immune responses relevant to rheumatic diseases.
  • Understanding host-microorganism homeostasis offers novel avenues for rheumatic disease prevention and treatment.
  • Targeting the gut microbiota presents a promising strategy for managing rheumatic conditions.